CJC 1295 without dac
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
CJC-1295 Without DAC — Modified GHRH Analog for Pulsatile GH Research
CJC-1295 Without DAC (Mod GRF 1-29) is a synthetic 29-amino acid GHRH analog with four substitutions (Ala2, Gln8, Ala15, Leu27) conferring DPP-IV resistance. Unlike the DAC version, it preserves natural pulsatile GH release, making it preferred for physiological GH secretion research.
Mechanism of Action
CJC-1295 Without DAC binds GHRH receptors on pituitary somatotrophs, activating the Gs-adenylyl cyclase-cAMP-PKA cascade for GH vesicle exocytosis. Half-life extended from ~7 min (native GRF 1-29) to 30+ min while maintaining pulsatile release kinetics essential for avoiding GH receptor desensitization.
Key Research Areas
- Pulsatile GH Secretion: Stimulates somatotrophs without sustained elevation, preserving the ultradian rhythm of GH secretion.
- Synergistic Secretagogue Research: Frequently combined with Ipamorelin — complementary GHRH + GHS-R pathways amplify GH release synergistically.
- Somatotroph Cell Biology: Tool for investigating GHRH receptor signaling, cAMP response, and GH gene transcription.
- DPP-IV Resistance Engineering: Model for studying how strategic amino acid substitutions extend peptide bioavailability.
Why Researchers Choose Peptides BioLab
Every batch of CJC-1295 Without DAC supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our CJC-1295 Without DAC is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: Ipamorelin, GHRP-6, and PEG-MGF. Browse our Growth Hormone Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
