Crystagen
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Crystagen (Glu-Asp-Pro) — Immune System Bioregulator for Immunological Research
Crystagen is a synthetic tripeptide bioregulator (Glu-Asp-Pro) developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. This immune-specific bioregulator has been characterized for its regulatory effects on immunocompetent cell function, particularly lymphocyte differentiation, cytokine network balance, and innate immune surveillance capacity. Published research in Bulletin of Experimental Biology and Medicine has documented its ability to restore age-diminished immune parameters and normalize immune homeostasis in both in-vitro and in-vivo experimental systems.
Mechanism of Action
Crystagen modulates gene expression in immunocompetent cells through the characteristic Khavinson bioregulator mechanism of direct DNA interaction. The EDP tripeptide binds specific nucleotide sequences in promoter regions of genes governing immune cell activation, differentiation, and effector function. Research has demonstrated modulation of cytokine gene expression profiles (IL-2, IFN-γ, IL-4, IL-10), normalization of T-helper 1/T-helper 2 balance, and upregulation of pattern recognition receptor (TLR) expression on innate immune cells, collectively enhancing immune surveillance without promoting excessive inflammatory activation.
Key Research Areas
- Lymphocyte Function: In-vitro studies on peripheral blood mononuclear cells (PBMCs) have demonstrated that Crystagen enhances mitogen-stimulated lymphocyte proliferation, increases CD3+ T-cell activation markers (CD25, CD69), and restores age-diminished cytokine production capacity.
- Innate Immunity: Research has shown that Crystagen upregulates phagocytic activity of monocytes and neutrophils, enhances natural killer cell cytotoxicity against K562 target cells, and increases reactive oxygen species generation capacity in professional phagocytes.
- Immunosenescence Reversal: Studies in aged rodent models have documented restoration of splenic T-cell zone architecture, normalization of naive/memory T-cell ratios, and enhanced response to vaccination protocols following Crystagen treatment.
- Cytokine Network Balance: Multiplex cytokine analysis has revealed that Crystagen normalizes the Th1/Th2/Th17/Treg balance in aged immune systems, reducing excessive inflammatory cytokine production while preserving protective immune responses.
Technical Specifications
- Dosage per vial: 10mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Sequence: Glu-Asp-Pro (EDP tripeptide)
- Molecular Weight: 359.33 Da
- Storage: -20°C, protected from light
Why Researchers Choose Peptides BioLab
Every batch of Crystagen supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying immune bioregulation may also find these compounds relevant: Vilon, Thymalin, and Thymosin Alpha-1. For a complete overview, browse our Recovery Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
