Vilon
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Vilon (Lys-Glu) — Thymic Dipeptide Bioregulator for Immune Research
Vilon (Lys-Glu) is a synthetic dipeptide bioregulator developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. As the shortest known peptide with demonstrated immunomodulatory activity, Vilon has been the subject of extensive research published in Bulletin of Experimental Biology and Medicine and other peer-reviewed journals. This dipeptide mimics the regulatory activity of thymic peptide extracts, modulating T-lymphocyte differentiation and immune function at remarkably low concentrations.
Mechanism of Action
Vilon interacts with specific DNA sequences in the promoter regions of genes involved in immune regulation, particularly those governing T-cell differentiation and cytokine production. Research has demonstrated that the Lys-Glu dipeptide binds to the minor groove of double-stranded DNA, modulating chromatin conformation and transcription factor accessibility. This epigenetic mechanism allows Vilon to regulate gene expression without direct receptor-mediated signaling, a hallmark of Khavinson's bioregulator peptide class.
Key Research Areas
- T-Cell Differentiation: In-vitro studies have demonstrated that Vilon promotes CD4+ and CD8+ T-lymphocyte maturation from thymocyte precursors, restoring thymic output parameters in aged animal models to levels comparable to younger controls.
- Immunosenescence: Research on aged rodent models has shown that Vilon administration normalizes the CD4/CD8 ratio, restores delayed-type hypersensitivity responses, and enhances natural killer cell cytotoxicity against tumor target cells.
- Gene Expression Modulation: Microarray studies have identified Vilon-responsive gene clusters involved in immune surveillance, apoptosis regulation, and antioxidant defense, demonstrating broad transcriptomic effects from a minimal peptide structure.
- Synergistic Bioregulation: Combined treatment with Vilon and Epitalon has shown enhanced immune restoration effects in preclinical models, suggesting complementary mechanisms between thymic and pineal bioregulators.
Technical Specifications
- Dosage per vial: 10mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Sequence: Lys-Glu (KE dipeptide)
- Molecular Weight: 275.30 Da
- Storage: -20°C, protected from light
Why Researchers Choose Peptides BioLab
Every batch of Vilon supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying thymic bioregulation and immunology may also find these compounds relevant: Thymalin, Thymosin Alpha-1, and LL-37. For a complete overview, browse our Recovery Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
