GHK Basic
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
GHK Basic — Tripeptide Growth Factor for Regenerative and Anti-Aging Research
GHK (Glycyl-L-Histidyl-L-Lysine) is a naturally occurring human tripeptide first identified by Pickart and Thaler in 1973 from human plasma. This simple three-amino acid sequence (Gly-His-Lys) was discovered through its ability to cause aged human liver tissue to synthesize proteins characteristic of younger tissue. Unlike its copper-bound form GHK-Cu, GHK Basic is supplied without the copper ion, allowing researchers to control the metallopeptide chemistry of their experimental systems. GHK naturally chelates copper(II) with high affinity (log K = 16.44) and will readily form the GHK-Cu complex when copper is present, making this format ideal for studies requiring precise control over copper delivery and speciation.
Mechanism of Action
GHK exerts broad biological effects through multiple mechanisms. Genomic studies published in Journal of Biomedicine and Biotechnology (2012) by Pickart et al. revealed that GHK modulates the expression of over 4,000 human genes, resetting gene expression patterns from aged profiles toward youthful configurations. Key pathways include upregulation of collagen synthesis genes (COL1A1, COL3A1), tissue inhibitors of metalloproteinases (TIMPs), and antioxidant response elements (Nrf2 pathway). GHK also stimulates decorin expression, which serves as a natural TGF-β trap, helping regulate fibrosis and tissue remodeling. Its copper-chelating function additionally supports the activity of copper-dependent enzymes including superoxide dismutase (SOD) and lysyl oxidase.
Key Research Areas
- Gene Expression Reprogramming: Comprehensive microarray analyses have demonstrated that GHK resets the expression of DNA repair genes, antioxidant genes, and stem cell-related genes toward patterns observed in younger tissues, providing a powerful model for studying the molecular mechanisms of tissue aging and rejuvenation.
- Extracellular Matrix Biology: GHK has been shown to stimulate collagen, elastin, and glycosaminoglycan synthesis in fibroblast cultures while simultaneously enhancing the breakdown of large, cross-linked collagen aggregates through controlled MMP regulation, promoting organized tissue remodeling.
- Metal Ion Biochemistry: The GHK Basic format enables researchers to study copper(II) chelation kinetics, metallopeptide formation constants, and the differential biological activity of apo-GHK versus holo-GHK-Cu complexes in controlled experimental settings.
- Wound Healing Models: Published studies have documented accelerated wound closure, enhanced angiogenesis, and improved tensile strength in dermal wound models treated with GHK, mediated through coordinated upregulation of growth factors including VEGF, FGF-2, and TGF-β1.
Why Researchers Choose Peptides BioLab
Every batch of GHK Basic supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our GHK Basic is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying copper peptide biology and tissue regeneration may also find these compounds relevant: GHK-Cu, AHK-Cu, and BPC-157. For a complete overview, browse our Anti-Aging Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
