AHK-CU
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
AHK-Cu — Copper Tripeptide Analog for Dermatological and Follicular Research
AHK-Cu (Ala-His-Lys-Cu) is a copper-binding tripeptide analog structurally related to GHK-Cu, designed to investigate dermatological regeneration and hair follicle biology. This peptide-copper complex has demonstrated affinity for copper(II) ions and activity in stimulating dermal papilla cell proliferation in published in-vitro research. As a next-generation copper peptide, AHK-Cu offers researchers a distinct molecular tool for studying extracellular matrix remodeling and follicular signaling pathways.
Mechanism of Action
AHK-Cu chelates copper(II) ions and delivers them to target cells, where copper serves as a cofactor for lysyl oxidase and other enzymes critical for collagen cross-linking and extracellular matrix assembly. Research published in the Journal of Cosmetic Dermatology has shown that AHK-Cu stimulates Wnt/β-catenin signaling in dermal papilla cells, a pathway essential for hair follicle morphogenesis and cycling. Additionally, the peptide has been observed to upregulate VEGF expression, potentially enhancing perifollicular vascularization in tissue models.
Key Research Areas
- Hair Follicle Biology: In-vitro studies using human dermal papilla cells have demonstrated that AHK-Cu promotes cell proliferation and upregulates growth factors associated with the anagen (growth) phase of the hair cycle, including FGF-7 and VEGF.
- Collagen Synthesis: Copper peptide complexes including AHK-Cu have been investigated for their role in stimulating type I and type III collagen production in fibroblast cultures, with potential applications in wound healing and skin aging research.
- Extracellular Matrix Remodeling: Research has examined how copper delivery via AHK-Cu modulates matrix metalloproteinase (MMP) activity, balancing tissue degradation and synthesis in skin equivalent models.
- Scalp Microenvironment: Studies have explored AHK-Cu's effects on the perifollicular microenvironment, including its influence on stem cell niche signaling and inflammatory cytokine modulation in scalp tissue models.
Why Researchers Choose Peptides BioLab
Every batch of AHK-Cu supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our AHK-Cu is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying copper peptide biology and dermatological pathways may also find these compounds relevant: GHK-Cu, SNAP-8, and Melanotan II. For a complete overview, browse our Dermatological Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
