Pancragen
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Pancragen (Lys-Glu-Asp-Trp) — Pancreatic Bioregulator Peptide for Metabolic Research
Pancragen is a synthetic tetrapeptide bioregulator (Lys-Glu-Asp-Trp) developed at the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. As a pancreas-specific bioregulator, Pancragen has been characterized for its selective modulatory effects on pancreatic islet cell gene expression, insulin secretion dynamics, and beta cell resilience. Research published in Bulletin of Experimental Biology and Medicine has documented its capacity to normalize glycemic regulation parameters and preserve islet architecture in aged and metabolically stressed animal models.
Mechanism of Action
Pancragen interacts with specific DNA sequences in promoter regions of genes critical for pancreatic islet function. The KEDW tetrapeptide modulates chromatin accessibility at loci encoding insulin (INS gene), glucokinase (GCK), pancreatic duodenal homeobox-1 (PDX-1), and glucose transporter type 2 (GLUT2). Research has demonstrated that Pancragen restores age-diminished PDX-1 expression—the master transcription factor for beta cell identity and insulin gene transcription—in aged islet preparations, effectively reprogramming metabolic sensing capacity.
Key Research Areas
- Beta Cell Function: In-vitro glucose-stimulated insulin secretion (GSIS) assays have demonstrated that Pancragen restores first-phase insulin release kinetics in aged murine islets, normalizing the biphasic secretion pattern characteristic of healthy beta cells.
- Islet Preservation: Histological studies in aged rodent pancreatic tissue have shown maintained islet size distribution, preserved alpha/beta cell ratio, and reduced amyloid deposition following chronic Pancragen treatment.
- Metabolic Gene Expression: Transcriptomic analysis of Pancragen-treated islets has revealed normalized expression of key metabolic sensors including GCK, KATP channel subunits (SUR1/Kir6.2), and voltage-gated calcium channels essential for stimulus-secretion coupling.
- Cellular Energy Metabolism: Research has demonstrated enhanced mitochondrial membrane potential and ATP production in beta cells treated with Pancragen, improving the metabolic coupling efficiency between glucose sensing and insulin exocytosis.
Technical Specifications
- Dosage per vial: 10mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Sequence: Lys-Glu-Asp-Trp (KEDW tetrapeptide)
- Molecular Weight: 562.57 Da
- Storage: -20°C, protected from light
Why Researchers Choose Peptides BioLab
Every batch of Pancragen supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying pancreatic bioregulation and metabolic pathways may also find these compounds relevant: MOTS-c, SS-31, and AICAR. For a complete overview, browse our Cellular Energy Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
