SLU-PP-332
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
SLU-PP-332 — ERRα/γ Agonist for Exercise Mimetic and Metabolic Research
SLU-PP-332 is a synthetic ERRα/ERRγ agonist developed at Saint Louis University (ACS Chemical Biology, 2023). These orphan nuclear receptors are master regulators of mitochondrial biogenesis and oxidative metabolism. Novel exercise mimetic activating endurance-exercise transcriptional programs.
Mechanism of Action
SLU-PP-332 stabilizes active conformations of ERRα/ERRγ, enhancing transcription of PGC-1α, NRF1, TFAM, CPT1b, and oxidative phosphorylation complex genes. Increased fatigue-resistant fiber content and running endurance in mouse models.
Key Research Areas
- Exercise Mimetic Research: Recapitulates endurance training adaptations: fiber type shifting, mitochondrial density, oxidative capacity — via pharmacological ERR activation.
- ERR Nuclear Receptor Biology: One of few validated ERRα/γ agonists — separates ERR-dependent from ERR-independent exercise adaptations.
- Mitochondrial Biogenesis: Drives PGC-1α/NRF1/TFAM cascade for mitochondrial DNA replication and respiratory chain assembly.
- Fiber Type Specification: Increased slow-twitch myosin expression and oxidative enzyme activity — molecular determinants of fiber type composition.
Why Researchers Choose Peptides BioLab
Every batch of SLU-PP-332 supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our SLU-PP-332 is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: AICAR, 5-Amino-1MQ, and MOTS-c. Browse our Metabolic Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
