5-Amino1-mq
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
5-Amino-1MQ — A Selective NNMT Inhibitor for Metabolic Research
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule compound that has gained significant attention in metabolic research as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). First characterized in studies published by Neelakantan et al. (2017) in Biochemical Pharmacology, this compound has demonstrated notable effects on adipocyte metabolism and energy expenditure pathways in preclinical models, making it a valuable tool for researchers investigating obesity-related metabolic dysfunction.
Mechanism of Action
5-Amino-1MQ functions by selectively inhibiting NNMT, an enzyme that regulates cellular energy metabolism through the methylation of nicotinamide. By blocking NNMT activity, this compound increases intracellular NAD+ concentrations and activates the SAM-dependent methylation cycle. In adipocyte models, NNMT inhibition has been associated with increased expression of energy expenditure genes and reduced lipogenesis. Research published in Obesity (2018) demonstrated that NNMT inhibition led to significant reductions in fat mass without affecting lean tissue in murine models.
Key Research Areas
- Adipocyte Metabolism: In-vitro studies have shown that 5-Amino-1MQ reduces lipid accumulation in 3T3-L1 adipocytes by increasing NAD+ availability and stimulating sirtuin-dependent metabolic pathways. These findings suggest potential applications in obesity-related metabolic research.
- NAD+ Biosynthesis: By inhibiting NNMT, this compound redirects nicotinamide toward the NAD+ salvage pathway, effectively increasing cellular NAD+ pools. This mechanism is of particular interest to researchers studying age-related NAD+ decline and mitochondrial function.
- Energy Expenditure: Preclinical studies have observed increased oxygen consumption rates and thermogenic gene expression in white adipose tissue following NNMT inhibition, indicating enhanced cellular energy expenditure.
- Metabolic Syndrome Pathways: Researchers have investigated the compound's effects on insulin signaling and glucose homeostasis in diet-induced obesity models, with published data suggesting improvements in metabolic biomarkers.
Why Researchers Choose Peptides BioLab
Every batch of 5-Amino-1MQ supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our 5-Amino-1MQ is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying metabolic pathways and energy expenditure may also find these compounds relevant to their work: AOD-9604, AICAR, and MOTS-c. For a complete overview, browse our Metabolic Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
