AOD9604
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
AOD-9604 — Growth Hormone Fragment for Lipolytic Pathway Research
AOD-9604 is a modified 16-amino acid fragment (residues 177-191) of human growth hormone with an added N-terminal tyrosine. Developed at Monash University, it isolates GH lipolytic activity from growth-promoting and diabetogenic effects. Research in Obesity Research (2001) showed it stimulates lipolysis and inhibits lipogenesis without affecting IGF-1 or insulin resistance.
Mechanism of Action
AOD-9604 activates beta-3 adrenergic receptor pathways, stimulating hormone-sensitive lipase (HSL) in adipocytes. It does not compete for GH receptor binding or stimulate IGF-1 secretion. Studies also showed stimulation of proteoglycan and collagen synthesis in chondrocyte models.
Key Research Areas
- Lipolysis & Adipocyte Biology: Stimulates lipolysis dose-dependently while inhibiting de novo lipogenesis in adipocyte cultures.
- GH Signaling Dissection: Enables study of GH lipolytic domain independently from somatotropic and diabetogenic pathways.
- Cartilage Biology: Stimulates proteoglycan synthesis in bovine cartilage explants, investigated in osteoarthritis models.
- Metabolic Pathway Analysis: Tool for investigating beta-3 adrenergic signaling, cAMP-PKA cascade, HSL and perilipin phosphorylation.
Why Researchers Choose Peptides BioLab
Every batch of AOD-9604 supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our AOD-9604 is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: 5-Amino-1MQ, AICAR, and MOTS-c. Browse our Metabolic Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
