TB-500 Fragment
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
TB-500 Fragment — Active Core Sequence of Thymosin Beta-4 for Targeted Tissue Repair Research
TB-500 Fragment is a synthetic peptide corresponding to the active region (amino acids 17-23, Ac-SDKP) of Thymosin Beta-4 (Tβ4), a 43-amino acid polypeptide originally isolated from the thymus gland. While full-length TB-500 has been widely studied for its tissue repair and anti-inflammatory properties, this fragment isolates the minimum pharmacophoric sequence responsible for the compound's principal biological activities: actin sequestration, cell migration promotion, and anti-fibrotic signaling. This targeted fragment allows researchers to investigate structure-activity relationships within the Tβ4 sequence with greater molecular precision.
Mechanism of Action
The TB-500 Fragment retains the core Ac-SDKP tetrapeptide motif that interacts with G-actin monomers, modulating actin polymerization dynamics. By sequestering G-actin, the fragment influences lamellipodia formation and directional cell migration. Published studies in Annals of the New York Academy of Sciences have demonstrated that this active sequence promotes endothelial cell migration and tubulogenesis through upregulation of VEGF and Ang-1 expression. Additionally, Ac-SDKP has been shown to inhibit TGF-β/Smad signaling, reducing collagen I and III deposition by activated fibroblasts, which underlies its anti-fibrotic properties observed in preclinical cardiac and renal fibrosis models.
Key Research Areas
- Tissue Repair Mechanisms: Researchers have utilized TB-500 Fragment to study the minimal structural requirements for Tβ4-mediated tissue repair, demonstrating that the Ac-SDKP core sequence is sufficient to promote keratinocyte and fibroblast migration in wound healing assays.
- Anti-Fibrotic Pathways: Published studies in Kidney International have shown that Ac-SDKP inhibits renal fibrosis progression by suppressing TGF-β1/Smad3 signaling and reducing α-SMA expression in myofibroblasts, establishing a model for anti-fibrotic compound evaluation.
- Angiogenesis Research: The fragment has been studied in chorioallantoic membrane (CAM) and Matrigel plug assays, demonstrating pro-angiogenic activity through enhanced endothelial cell proliferation, migration, and capillary network formation.
- Cardiac Injury Models: Investigators have examined TB-500 Fragment's effects in murine myocardial infarction models, documenting reduced scar formation and improved cardiac function parameters, with mechanism studies pointing to both anti-inflammatory and pro-survival signaling.
Why Researchers Choose Peptides BioLab
Every batch of TB-500 Fragment supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our TB-500 Fragment is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying tissue repair and regenerative pathways may also find these compounds relevant: TB-500, BPC-157, and GHK-Cu. For a complete overview, browse our Recovery Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
