Adamax
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Adamax (Adamantyl-Semax) — Enhanced Nootropic Peptide for Cognitive Research
Adamax, also known as Adamantyl-Semax, is a structurally modified derivative of Semax (MEHFPGP) featuring an adamantane group conjugation that enhances blood-brain barrier penetration and receptor binding affinity. Building upon the extensive research foundation of Semax, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Adamax represents a next-generation nootropic research tool. The adamantane modification—a strategy also employed in pharmaceutical compounds like amantadine and memantine—confers increased lipophilicity and metabolic stability compared to the parent peptide.
Mechanism of Action
Adamax retains and enhances Semax's primary mechanisms while exhibiting improved pharmacokinetic properties. The compound activates melanocortin MC3 and MC4 receptor subtypes in the central nervous system, stimulating BDNF and NGF expression through CREB-dependent transcriptional activation. The adamantane moiety increases membrane permeability and provides steric protection against enzymatic degradation, resulting in prolonged receptor engagement. Additional research suggests NMDA receptor modulation and enhanced cholinergic transmission in hippocampal circuits.
Key Research Areas
- Neurotrophic Factor Expression: Comparative studies have demonstrated that Adamax produces significantly greater BDNF mRNA upregulation in hippocampal neuronal cultures compared to equimolar concentrations of native Semax, suggesting enhanced potency from the adamantane modification.
- Cognitive Enhancement: Behavioral studies in rodent models have shown improvements in spatial learning (radial arm maze), working memory (delayed match-to-sample), and attention (5-choice serial reaction time task) following Adamax administration.
- Neuroprotection: In ischemia-reperfusion models, Adamax has demonstrated reduced infarct volume and preserved neuronal density in the CA1 hippocampal region, with effects superior to those observed with native Semax at equivalent doses.
- Pharmacokinetic Enhancement: In-vivo distribution studies have confirmed increased CNS bioavailability of the adamantyl conjugate compared to unmodified Semax, with detectable peptide levels in cerebrospinal fluid at lower peripheral doses.
Technical Specifications
- Dosage per vial: 10mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Storage: -20°C, protected from light
Why Researchers Choose Peptides BioLab
Every batch of Adamax supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying nootropic peptides and cognitive enhancement may also find these compounds relevant: Semax, Selank, and NA Semax Amidate. For a complete overview, browse our Cognitive Function Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
