Semax
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Semax — ACTH(4-10) Analog for Neurotrophic Factor and Cognitive Research
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic ACTH(4-10) analog developed at the Institute of Molecular Genetics, Russian Academy of Sciences. Pro-Gly-Pro extension confers protease resistance without steroidogenic effects. Over 200 published studies on neurotrophic factor expression and cognitive performance.
Mechanism of Action
Semax upregulates BDNF and TrkB in hippocampus and cortex, increases NGF expression, enhances 5-HT turnover, and activates the MAPK/ERK cascade for neuronal survival under ischemic conditions.
Key Research Areas
- BDNF & NGF Upregulation: Sustained increases in hippocampal BDNF and cortical NGF — enhanced neurotrophic support documented across independent research groups.
- Cognitive Enhancement Models: Improved Morris water maze, passive avoidance, and novel object recognition correlating with increased LTP.
- Neuroprotection: Reduces infarct volume, preserves BBB integrity, maintains neuronal viability in stroke models.
- Gene Expression Profiling: Transcriptomic analysis reveals modulation of neurotransmitter, immune, vascular, and neuroprotection genes.
Why Researchers Choose Peptides BioLab
Every batch of Semax supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our Semax is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: Selank, PE-22-28, and Pinealon. Browse our Nootropic & Cognitive Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
