NA Semax Amidate
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
NA Semax Amidate — Enhanced ACTH Analog for Neurotrophic and Cerebrovascular Research
N-Acetyl Semax Amidate is a stabilized derivative of Semax, the synthetic heptapeptide analog of the ACTH(4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been studied extensively for its pronounced neurotrophic, neuroprotective, and cognitive-enhancing properties. The N-acetyl amidate modification significantly increases the peptide's resistance to aminopeptidase and carboxypeptidase degradation, resulting in an extended half-life and enhanced potency compared to the parent compound in research settings.
Mechanism of Action
NA Semax Amidate exerts its effects through multiple converging pathways. Research published in Neuroscience Letters (2006) demonstrated that Semax analogs rapidly upregulate BDNF and NGF (nerve growth factor) expression in cortical and hippocampal tissues through TrkB receptor-mediated signaling cascades. The compound also modulates dopaminergic and serotoninergic neurotransmission, increasing dopamine and serotonin turnover in the striatum and nucleus accumbens. Additionally, published data in Doklady Biological Sciences have shown that Semax analogs influence gene expression patterns related to neurovascular coupling and cerebral blood flow autoregulation.
Key Research Areas
- Neurotrophic Factor Expression: In-vitro and in-vivo studies have demonstrated that NA Semax Amidate upregulates BDNF, NGF, and NT-3 expression in glial and neuronal cell populations. Research in Brain Research (2007) documented a 2-3 fold increase in BDNF mRNA levels in the hippocampus following administration.
- Cognitive Performance: Behavioral studies using novel object recognition, radial arm maze, and contextual fear conditioning paradigms have shown significant enhancements in learning acquisition and memory retention in rodent models treated with Semax analogs, with the stabilized form demonstrating prolonged effect duration.
- Cerebrovascular Research: Investigators have studied the compound's effects on cerebral hemodynamics, documenting improved cerebral blood flow autoregulation and reduced infarct volume in models of focal cerebral ischemia, mediated through NO-dependent vasodilation and neurovascular unit protection.
- Neuroinflammation: Research has demonstrated that NA Semax Amidate modulates microglial activation states, promoting the M2 anti-inflammatory phenotype while attenuating pro-inflammatory cytokine release (IL-1β, TNF-α) in lipopolysaccharide-challenged neuronal co-cultures.
Why Researchers Choose Peptides BioLab
Every batch of NA Semax Amidate supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our NA Semax Amidate is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying neurotrophic signaling and cognitive enhancement may also find these compounds relevant: Semax, Selank, and Dihexa. For a complete overview, browse our Cognitive Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
