Adipotide
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Adipotide (CKGGRAKDC-GG-D(KLAKLAK)₂) — Proapoptotic Vascular-Targeting Peptide for Obesity Research
Adipotide, also designated as Prohibitin-TP01, is a chimeric peptidomimetic composed of a vascular homing domain (CKGGRAKDC) linked to a proapoptotic sequence D(KLAKLAK)₂. Originally developed at the University of Texas MD Anderson Cancer Center and published by Kolonin et al. (2004) in Nature Medicine, Adipotide selectively targets prohibitin on the surface of blood vessels supplying white adipose tissue, inducing targeted apoptosis in adipose vasculature. This unique mechanism provides researchers with a tool for studying vascular-targeted approaches to adipose tissue remodeling.
Mechanism of Action
The CKGGRAKDC motif of Adipotide binds with high affinity to prohibitin, a receptor specifically expressed on the endothelial surface of white adipose tissue vasculature. Upon receptor binding, the conjugated D(KLAKLAK)₂ domain—a synthetic peptide engineered to disrupt mitochondrial membranes—is internalized into endothelial cells via receptor-mediated endocytosis. Once intracellular, the proapoptotic domain permeabilizes mitochondrial membranes, triggering cytochrome c release and caspase-mediated apoptosis selectively in adipose vascular endothelium.
Key Research Areas
- Targeted Adipose Ablation: In non-human primate studies published in Science Translational Medicine (2012), Adipotide treatment resulted in significant dose-dependent reductions in body mass index, abdominal circumference, and total body fat measured by DEXA scanning.
- Vascular Biology of Adipose Tissue: The compound has enabled researchers to map prohibitin expression patterns across different adipose depots, revealing heterogeneity in vascular surface receptor profiles between visceral and subcutaneous fat.
- Metabolic Parameter Modulation: Preclinical studies observed improvements in insulin sensitivity and lipid profiles concurrent with adipose mass reduction, providing insights into the relationship between adipose vascularization and metabolic health.
- Peptide-Drug Conjugate Design: Adipotide serves as a prototype for vascular-targeted peptide therapeutics, informing researchers designing next-generation tissue-selective delivery systems.
Technical Specifications
- Dosage per vial: 5mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Storage: -20°C, protected from light and moisture
Why Researchers Choose Peptides BioLab
Every batch of Adipotide supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying adipose biology and metabolic regulation may also find these compounds relevant: AOD-9604, 5-Amino-1MQ, and MOTS-c. For a complete overview, browse our Weight Loss Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
