HGH Fragment 176-191
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
HGH Fragment 176-191 — Growth Hormone Lipolytic Domain for Metabolic Research
HGH Fragment 176-191 is a modified segment of the human growth hormone (hGH) molecule, corresponding to amino acids 176 through 191 of the C-terminal region. This peptide fragment retains the lipolytic activity of full-length hGH without its growth-promoting or diabetogenic properties. Research published by Ng et al. (2000) in Endocrinology first characterized this fragment's ability to stimulate lipolysis and inhibit lipogenesis in adipose tissue models, establishing it as a valuable research tool for studying fat metabolism independent of IGF-1 axis activation.
Mechanism of Action
HGH Fragment 176-191 acts on adipocytes through a mechanism distinct from full-length growth hormone. While hGH stimulates lipolysis via JAK2/STAT5 signaling, the 176-191 fragment appears to engage a beta-3 adrenergic receptor-mediated pathway, enhancing cyclic AMP production and activating hormone-sensitive lipase (HSL). Importantly, this fragment does not compete for GH receptor binding and does not stimulate IGF-1 secretion, providing researchers with a tool to study fat-specific metabolic effects in isolation.
Key Research Areas
- Lipolysis and Fat Metabolism: In-vitro studies on human and murine adipocytes have demonstrated that HGH Fragment 176-191 stimulates lipolysis at rates comparable to full-length hGH, while exhibiting no effect on longitudinal bone growth or glucose homeostasis.
- Anti-Lipogenic Activity: Research has shown this fragment inhibits de novo lipogenesis in adipocyte cultures, reducing fatty acid synthase (FAS) expression and decreasing triglyceride accumulation in dose-dependent fashion.
- Metabolic Selectivity: Unlike full-length hGH, the 176-191 fragment does not impair insulin sensitivity in preclinical models, making it a tool for studying lipolytic pathways without confounding hyperglycemic effects.
- Obesity Research Models: Chronic administration studies in ob/ob mouse models have demonstrated reductions in body fat percentage without changes in food intake or lean body mass.
Technical Specifications
- Dosage per vial: 5mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Sequence: H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH
- Storage: -20°C, protected from light
Why Researchers Choose Peptides BioLab
Every batch of HGH Fragment 176-191 supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying fat metabolism and growth hormone pathways may also find these compounds relevant: AOD-9604, 5-Amino-1MQ, and MOTS-c. For a complete overview, browse our Weight Loss Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
