NA Selank Amidate
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
NA Selank Amidate — Stabilized Anxiolytic Neuropeptide for Cognitive and Immunomodulatory Research
N-Acetyl Selank Amidate is a modified analog of Selank, the synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank has been extensively studied for its anxiolytic, nootropic, and immunostimulatory properties. The N-acetyl amidate modification confers superior enzymatic stability by protecting both the N-terminal (via acetylation) and C-terminal (via amidation) from exopeptidase degradation, resulting in significantly enhanced bioavailability and prolonged biological activity in research applications.
Mechanism of Action
NA Selank Amidate modulates the GABAergic system by allosterically influencing GABA-A receptor sensitivity, without directly binding the benzodiazepine site. Published research in Bulletin of Experimental Biology and Medicine (2008) demonstrated that Selank analogs increase BDNF (brain-derived neurotrophic factor) mRNA expression in the hippocampus and frontal cortex, promoting neuroplasticity. Additionally, the compound has been shown to modulate the expression of IL-6, IL-10, and TNF-α, suggesting dual neuroimmune regulatory activity. The stabilized form enhances these effects by maintaining effective concentrations over extended experimental timeframes.
Key Research Areas
- Anxiolytic Mechanisms: In behavioral models (elevated plus maze, open field test), NA Selank Amidate has demonstrated anxiolytic effects comparable to benzodiazepines without sedation, motor impairment, or dependence potential. Studies in Behavioural Brain Research (2009) documented significant reductions in anxiety-like behavior in rodent models.
- Cognitive Enhancement: Research has shown that Selank analogs enhance memory consolidation and retrieval in passive avoidance and Morris water maze paradigms, mediated through increased BDNF expression and enhanced monoamine neurotransmitter metabolism in hippocampal and prefrontal regions.
- Immunomodulation: As a tuftsin analog, NA Selank Amidate stimulates phagocytic activity and modulates cytokine profiles. Published studies have documented increased natural killer cell activity and balanced Th1/Th2 immune responses in treated animal models.
- Neuroprotection: Investigators have examined the compound's ability to protect neurons from oxidative stress-induced apoptosis, with evidence of enhanced SOD activity and reduced lipid peroxidation markers in cortical neuron cultures following treatment.
Why Researchers Choose Peptides BioLab
Every batch of NA Selank Amidate supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our NA Selank Amidate is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying anxiolytic neuropeptides and cognitive enhancement may also find these compounds relevant: Selank, Semax, and Dihexa. For a complete overview, browse our Cognitive Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
