NAD+
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
NAD+ — Essential Coenzyme for Sirtuin and Cellular Aging Research
NAD+ (Nicotinamide Adenine Dinucleotide) is a fundamental coenzyme in 500+ enzymatic reactions. Critical substrate for sirtuins (SIRT1-7), PARPs, and CD38 — regulating DNA repair, epigenetics, circadian rhythms, and inflammation. Declining NAD+ is a hallmark of aging (Imai & Guarente, Trends in Cell Biology, 2014).
Mechanism of Action
NAD+ participates in redox reactions (NAD+/NADH) and is consumed by sirtuins for protein deacetylation, linking metabolic state to epigenetic regulation. PARP1 consumes NAD+ for DNA repair. NAD+ repletion restores mitochondrial function in aged mice (Science, 2013). CD38 identified as primary driver of age-related NAD+ decline.
Key Research Areas
- Sirtuin Biology: Absolute requirement for SIRT1 deacetylation of PGC-1α, FOXO, and histone H3K9 — linking metabolism to gene regulation.
- DNA Repair & Genomic Stability: PARP1/2 consume NAD+ for poly(ADP-ribose) chains at damage sites. Depletion compromises repair capacity.
- Mitochondrial Function: NAD+/NADH ratio drives ETC flux and ATP production. Restoring levels rescues membrane potential in aged tissues.
- Circadian Clock: NAD+ oscillates with NAMPT expression cycles. SIRT1 deacetylates BMAL1 and PER2 in NAD+-dependent manner.
Why Researchers Choose Peptides BioLab
Every batch of NAD+ supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our NAD+ is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
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Researchers studying related pathways may also find these compounds relevant: SS-31, Glutathione, and Epitalon. Browse our Longevity Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
