Testagen
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Testagen (Lys-Glu-Asp-Gly) — Testicular Bioregulator Peptide for Reproductive Research
Testagen is a synthetic tetrapeptide bioregulator (Lys-Glu-Asp-Gly) developed at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson's research group. As a tissue-specific bioregulator targeting testicular function, Testagen has been investigated for its capacity to normalize gonadal peptide regulation and modulate Leydig cell activity in preclinical models. Published research in Bulletin of Experimental Biology and Medicine has demonstrated its role in restoring age-related declines in reproductive hormone synthesis and spermatogenesis parameters.
Mechanism of Action
Testagen operates through the characteristic bioregulator mechanism described by Khavinson—direct interaction with specific DNA sequences to modulate gene expression. The KEDG tetrapeptide has been shown to bind complementary nucleotide sequences in the promoter regions of genes involved in steroidogenesis, particularly those encoding steroidogenic acute regulatory protein (StAR) and cytochrome P450 enzymes (CYP11A1, CYP17A1) essential for testosterone biosynthesis. This epigenetic regulation normalizes transcriptional activity without supraphysiological stimulation.
Key Research Areas
- Leydig Cell Function: In-vitro studies on primary Leydig cell cultures have demonstrated that Testagen restores testosterone production capacity in cells exposed to age-mimicking oxidative stress conditions, increasing StAR protein expression and cholesterol transport to mitochondria.
- Spermatogenesis: Research in aged rodent models has shown normalization of spermatogenic epithelium architecture and increased sperm motility parameters following Testagen administration, with effects persisting beyond the treatment period.
- Neuroendocrine Regulation: Studies have observed restoration of hypothalamic-pituitary-gonadal (HPG) axis sensitivity in aged models, with normalized GnRH pulsatility and LH response patterns.
- Reproductive Aging: Long-term studies have investigated Testagen's capacity to delay age-related testicular involution, with histological analyses showing preserved seminiferous tubule integrity and interstitial tissue architecture.
Technical Specifications
- Dosage per vial: 10mg lyophilized powder
- Purity: ≥98% (HPLC verified)
- Sequence: Lys-Glu-Asp-Gly (KEDG)
- Molecular Weight: 433.46 Da
- Storage: -20°C, protected from light
Why Researchers Choose Peptides BioLab
Every batch of Testagen supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our product is supplied as a lyophilized powder for maximum stability, shipped worldwide in temperature-controlled packaging.
Related Research Peptides
Researchers studying reproductive biology and endocrine regulation may also find these compounds relevant: Kisspeptin, Melanotan II, and PT-141. For a complete overview, browse our Sexual Health Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
