Kisspeptin
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Kisspeptin-10 — KISS1R Agonist for Reproductive Neuroendocrinology Research
Kisspeptin-10 is the C-terminal decapeptide of the KISS1 gene product, a critical HPG axis regulator. Identified as GPR54 ligand by de Roux et al. and Seminara et al. (2003, NEJM). Loss-of-function KISS1R mutations cause hypogonadotropic hypogonadism.
Mechanism of Action
Kisspeptin-10 binds KISS1R (GPR54), a Gq/11 receptor on GnRH neurons, triggering PLC-calcium mobilization and GnRH pulsatile secretion → LH and FSH release. Arcuate KNDy neurons generate the GnRH pulse essential for gonadotropin secretion.
Key Research Areas
- GnRH Pulse Generator: Critical component of the GnRH pulse generator via arcuate KNDy neurons (kisspeptin + neurokinin B + dynorphin).
- Puberty Research: Kisspeptin signaling increases dramatically at puberty — study neuroendocrine mechanisms of pubertal GnRH activation.
- Fertility and Ovulation: Triggers LH surges comparable to ovulation requirements, studying positive estrogen feedback on HPG axis.
- Metabolic-Reproductive Integration: Kisspeptin neurons receive leptin, insulin, and glucose inputs — nexus for energy-reproductive competence research.
Why Researchers Choose Peptides BioLab
Every batch of Kisspeptin-10 supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our Kisspeptin-10 is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: PT-141, VIP, and Melanotan II. Browse our Endocrine Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
