PT 141
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
PT-141 — Selective MC3R/MC4R Agonist for Central Melanocortin Research
PT-141 (Bremelanotide) is a cyclic heptapeptide derived from Melanotan II via C-terminal carboxylation. Selective for MC3R/MC4R over MC1R — minimal melanogenic activity while retaining CNS effects. Key tool for hypothalamic melanocortin signaling research.
Mechanism of Action
PT-141 activates MC4R/MC3R in hypothalamic nuclei via Gs-cAMP signaling. Effects mediated through CNS pathways, not peripheral vascular mechanisms. MC4R activation triggers descending spinal projections to autonomic preganglionic neurons, modulating sympathetic and parasympathetic outflow.
Key Research Areas
- MC4R Signaling: Selective tool for studying MC4R-mediated CNS signaling distinct from peripheral MC1R activation.
- Autonomic Nervous System: Modulates autonomic outflow through hypothalamic-spinal pathways, studying central melanocortin regulation of peripheral function.
- Melanocortin Structure-Activity: Metabolite-derived analog showing how subtle modifications alter MC receptor subtype selectivity.
- Neuroendocrine Integration: MC4R neurons integrate leptin, insulin, and orexin inputs — studying converging hypothalamic pathways.
Why Researchers Choose Peptides BioLab
Every batch of PT-141 supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our PT-141 is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: Melanotan II, Kisspeptin, and VIP. Browse our Neurological Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
