VIP
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
VIP — Vasoactive Intestinal Peptide for Neuroimmune and Mucosal Research
VIP is a 28-amino acid neuropeptide (Said & Mutt, 1970). Neurotransmitter and immune modulator acting through VPAC1/VPAC2 receptors across nervous, immune, endocrine, and GI systems. Over 10,000 published articles.
Mechanism of Action
VIP activates VPAC1/2 via Gs-cAMP signaling. In neurons: modulates synaptic transmission and circadian rhythm (key SCN synchronizer). In immune cells: generates tolerogenic DCs, promotes Tregs, shifts Th1→Th2 (Nat Rev Immunol). In gut: regulates ion transport, blood flow, smooth muscle.
Key Research Areas
- Neuroimmune Modulation: VIPergic nerves innervate lymphoid organs — studies how neuropeptide signaling regulates immune function.
- Circadian Clock Research: Essential for SCN neuronal synchronization. VPAC2 signaling maintains intercellular clock coupling.
- Regulatory T-Cell Biology: Promotes FoxP3+ Treg differentiation — peripheral tolerance and immune homeostasis mechanisms.
- Gut-Brain Axis: Abundant enteric neuropeptide regulating secretion, motility, barrier function, and mucosal immune responses.
Why Researchers Choose Peptides BioLab
Every batch of VIP supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our VIP is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: ARA-290, Thymosin Alpha-1, and LL-37. Browse our Neurological Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
