ACE-031
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
ACE-031 — Soluble ActRIIB Decoy Receptor for Myostatin Pathway Research
ACE-031 is a recombinant fusion protein consisting of the extracellular domain of activin receptor type IIB (ActRIIB) fused to the Fc portion of human IgG1. This soluble decoy receptor binds and neutralizes members of the TGF-β superfamily, including myostatin and activins, which are negative regulators of skeletal muscle mass. Originally developed by Acceleron Pharma and studied in clinical trials for neuromuscular conditions, ACE-031 remains a critical research tool for investigating muscle growth regulation pathways.
Mechanism of Action
ACE-031 functions as a ligand trap, sequestering myostatin (GDF-8) and related TGF-β family ligands before they can bind to endogenous ActRIIB receptors on cell surfaces. By intercepting these signaling molecules, the compound effectively blocks the SMAD2/3 phosphorylation cascade that normally suppresses muscle protein synthesis. Studies published in Molecular and Cellular Endocrinology (2010) demonstrated that ActRIIB-Fc administration in murine models resulted in significant increases in lean muscle mass, independent of physical activity.
Key Research Areas
- Myostatin Inhibition: ACE-031 has been extensively studied as a myostatin antagonist. In preclinical models, treatment resulted in dose-dependent increases in skeletal muscle mass, with research in Muscle & Nerve (2013) documenting significant effects on both fast-twitch and slow-twitch fiber types.
- Neuromuscular Disease Models: Researchers have investigated ACE-031 in the mdx mouse model of Duchenne muscular dystrophy, where it demonstrated preservation of muscle function and reduced fibrosis without directly targeting the underlying genetic defect.
- Bone Mineral Density: Published research has observed concurrent increases in bone mineral density alongside muscle mass gains, suggesting dual anabolic effects mediated through TGF-β pathway modulation.
- Metabolic Regulation: ActRIIB pathway blockade has been associated with reduced adiposity in animal models, with researchers observing improved glucose tolerance and insulin sensitivity alongside muscle hypertrophy.
Why Researchers Choose Peptides BioLab
Every batch of ACE-031 supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our ACE-031 is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying muscle growth regulation and TGF-β signaling may also find these compounds relevant: Follistatin 344, IGF-1 LR3, and PEG-MGF. For a complete overview, browse our Growth Hormone Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
