Follistatin 344
Lab-Tested ≥98% Purity · Certificate of Analysis Included · Global Shipping
Follistatin 344 — Activin-Binding Glycoprotein for Myostatin Antagonism Research
Follistatin 344 (FST344) is a 344-amino acid glycoprotein that antagonizes activin, myostatin (GDF-8), and other TGF-β superfamily ligands. Research in FASEB Journal (2005) showed dramatic skeletal muscle mass increases in multiple animal models.
Mechanism of Action
Follistatin neutralizes TGF-β members through direct protein-protein interactions. Its three FS domains create a binding surface complementary to activin and myostatin receptor-binding epitopes, preventing ActRII/ALK4 activation and SMAD2/3 signaling. PNAS research showed sustained muscle mass increases in non-human primate gene delivery models.
Key Research Areas
- Myostatin Antagonism: Binds myostatin with nanomolar affinity, preventing ActRIIB signaling. Studied for effects on muscle fiber hypertrophy and satellite cell proliferation.
- Activin Signaling: Regulates activin A/B signaling influencing reproductive biology, inflammatory responses, and hepatic glucose metabolism.
- Gene Therapy Models: Used in AAV-mediated gene delivery for sustained muscle mass — proof-of-concept for neuromuscular gene therapy.
- Muscle Regeneration: Enhances satellite cell activation and myoblast fusion in damaged muscle tissue.
Why Researchers Choose Peptides BioLab
Every batch of Follistatin 344 supplied by Peptides BioLab undergoes rigorous HPLC and mass spectrometry analysis, ensuring ≥98% purity verified by an independent Certificate of Analysis (CoA). Our Follistatin 344 is supplied as a lyophilized powder for maximum stability and shelf life, shipped worldwide from our state-of-the-art facilities in temperature-controlled packaging.
Related Research Peptides
Researchers studying related pathways may also find these compounds relevant: ACE-031, IGF-1 LR3, and PEG-MGF. Browse our Growth Hormone Research collection.
For research purposes only — Not for human consumption. All products are intended solely for in-vitro research and laboratory use.
Every Peptides BioLab product includes a Certificate of Analysis (CoA) with HPLC and MS data confirming ≥98% purity. The CoA is available in the product tabs as the 2nd image, or contact our team to request a copy.
Shipping: We ship worldwide from our state-of-the-art facilities. Orders are processed within 1–2 business days. Express and standard shipping options available at checkout.
Storage: Store lyophilized peptides at -20°C for long-term storage. Once reconstituted, store at 2–8°C and use within 30 days. Keep away from direct sunlight.
